Senior Director, PMO Strategic Portfolio Management & AI Innovation

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we’re in. Are you?

About the Role

Seeking a dynamic Senior Director to join our Program Management Operations (PMO) team. Reporting to the Executive Director, Portfolio Strategy & PMO, this role is critical in driving AI-enabled portfolio strategy initiatives, overseeing comprehensive portfolio reporting, and leading the planning and execution of strategic and operational initiatives across Insmed's portfolio. This role offers an exciting opportunity to leverage cutting-edge AI technologies and data analytics to optimize portfolio decisions, transform reporting capabilities, and contribute to bringing innovative therapies to patients with serious diseases.

What You'll Do

In this role, you will design and execute strategic initiatives that optimize portfolio performance and resource allocation. Additionally, you will collaborate with cross-functional teams to integrate AI and machine learning capabilities into portfolio management and reporting processes

You will also have responsibility for

Portfolio Reporting & Analytics

• Design and implement AI-enabled reporting frameworks that automate data collection, analysis, and visualization
• Develop advanced analytics dashboards and predictive modeling tools for portfolio performance monitoring
• Leverage AI/ML technologies to identify portfolio-level risks, trends, opportunities, and strategic insights from reporting data
• Establish standardized reporting metrics, KPIs, and governance processes across the portfolio

Strategic Portfolio Management

• Lead the development and implementation of AI-driven portfolio strategy frameworks and decision-making tools
• Support senior leadership in strategic planning and portfolio optimization decisions based on data-driven insights
• Provide strategic oversight and guidance on portfolio prioritization and resource allocation

AI Innovation & Process Excellence

• Lead operational excellence initiatives across the PMO organization
• Identify opportunities for process improvement and automation using AI/ML technologies
• Develop and maintain portfolio analytics platforms that enable real-time decision-making

Cross-Functional Leadership

• Manage complex, multi-functional strategic projects from conception to completion
• Coordinate activities across Business Development, Program Management, Commercial, Regulatory Affairs, Medical Affairs, Technical Operations, Clinical Development, and Finance

Who You Are

You have an advanced degree in business, engineering, data science, life sciences, or related field, and a minimum 10-12 years of strategic planning, portfolio management, or management consulting experience, with at least 5 years in pharmaceutical/biotechnology industry

Additionally you have

• Proven experience with AI/ML applications in business strategy, portfolio management, or reporting/analytics
• Strong understanding of drug development processes and pharmaceutical business modelsExpertise in data analytics, predictive modeling, business intelligence tools, and reporting platforms
• Experience with portfolio reporting, performance measurement, and executive-level communications
• Entrepreneurial self-starter with a proven track record of success in fast-paced environments
• Well-developed technical skills (Python/R, SQL, Tableau/PowerBI, Excel, PowerPoint, MS Teams/SharePoint)

Preferred Qualifications

• MBA or advanced degree in data science, AI/ML, or related technical field
• Experience in respiratory diseases, immunology & inflammation, neurology/neuroscience, and/or rare diseases
• Knowledge of AI/ML platforms and tools (TensorFlow, PyTorch, cloud-based ML services)
• Project Management Professional (PMP) or similar certification
• Experience with portfolio optimization and resource allocation methodologies
• Background in business intelligence, data visualization, and automated reporting system

Travel Requirements

This role requires occasional domestic travel approximately <10%

Where You’ll Work

This is a hybrid role based out of our Bridgewater, NJ Headquarters. You’ll work remotely most of the time, with in-person collaboration when it matters most.

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#LI-SK - Hybrid

Pay Range

$177,000.00-242,000.00 Annual

Life at Insmed

At Insmed, you’ll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S.

offerings include

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees

Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. For more information, please refer to our Equal Employment Opportunity and Non-Discrimination Statement on our Careers site.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.