Research Scientist

• We are seeking an Research scientist to join the CTI-GBT group in our antibody-based therapeutic discovery efforts
• The successful candidate will be responsible for lead selection and optimization to develop various immuno-oncology therapeutic modalities employing molecular biology, biochemistry, structural modeling and antibody engineering skills
• The candidate is expected to contribute to more than one therapeutic program in parallel, design and execute antibody screening and engineering campaigns employing advanced biochemistry and cell biology techniques and assess therapeutic intervention employing appropriate antibody modalities
• Developing, optimizing and executing high throughout binding assays (ELISA, Octet) for screening antibody panels
• Optimization of antibodies and alternate formats to fit the biology using antibody engineering techniques
• Developing cell based assays to characterize hits and leads for binding to Fc receptors and targets expressed on primary cells, assessing effector functions utilizing various sources of effector cells, retargeting tumor cells to different immune cell types and measuring cytotoxicity.
• BS/MS or advanced degree preferred with equivalent experience
• Experience with ELISA and FACs based cytometry
• Experience with protein purification or AKTA is desired
• 2+ years of experience with cell plate ELISA and high throughput screening

Regards

Ricky